TGFβ and activin A in the tumor microenvironment in colorectal cancer.

ABSTRACT: Although overall survival in colorectal cancer (CRC) is increasing steadily due to progress in screening, therapeutic options and precise diagnostic tools remain scarce. As the understanding of CRC as a complex and multifactorial condition moves forward, the tumor microenvironment has come into focus as a source of diagnostic markers and potential therapeutic targets. The role of TGFβ in shifting the epithelial cancer compartment towards invasiveness and a pro-migratory phenotype via stromal signaling has been widely investigated. Accordingly, recent studies have proposed that CRC patients could be stratified into distinct subtypes and have identified one poor prognosis subset of CRC that is characterized by high stromal activity and elevated levels of TGFβ. The TGFβ superfamily member act

SUBMITTER: Zessner-Spitzenberg J 

PROVIDER: S-EPMC7061929 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature