An atlas of transposable element-derived alternative splicing in cancer.

ABSTRACT: Transposable element (TE)-derived sequences comprise more than half of the human genome, and their presence has been documented to alter gene expression in a number of different ways, including the generation of alternatively spliced transcript isoforms. Alternative splicing has been associated with tumorigenesis for a number of different cancers. The objective of this study was to broadly characterize the role of human TEs in generating alternatively spliced transcript isoforms in cancer. To do so, we screened for the presence of TE-derived sequences co-located with alternative splice sites that are differentially used in normal versus cancer tissues. We analysed a comprehensive set of alternative splice variants characterized for 614 matched normal-tumour tissue pairs across 13 cancer ty

SUBMITTER: Clayton EA 

PROVIDER: S-EPMC7061986 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature