Control of synchronization ratios in clock/cell cycle coupling by growth factors and glucocorticoids.

ABSTRACT: The cell cycle and the circadian clock are essential cyclic cellular processes often synchronous in healthy cells. In this work, we use previously developed mathematical models of the mammalian cell cycle and circadian cellular clock in order to investigate their dynamical interactions. Firstly, we study unidirectional cell cycle → clock coupling by proposing a mechanism of mitosis promoting factor (MPF)-controlled REV-ERBα degradation. Secondly, we analyse a bidirectional coupling configuration, where we add the CLOCK : BMAL1-mediated MPF repression via the WEE1 kinase to the first system. Our simulations reproduce ratios of clock to cell cycle period in agreement with experimental observations and give predictions of the system's synchronization state response to a variety of control par

SUBMITTER: Almeida S 

PROVIDER: S-EPMC7062057 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature