Quaternary-centre-guided synthesis of complex polycyclic terpenes.

ABSTRACT: The presence of a quaternary centre-a carbon with four other carbons bonded to it-in any given molecule can have a substantial chemical and biological impact. In many cases, it can enable otherwise challenging chemistry. For example, quaternary centres induce large rate enhancements in cyclization reactions-known as the Thorpe-Ingold effect-which has application in drug delivery for molecules with modest bioavailability¹. Similarly, the addition of quaternary centres to a drug candidate can enhance both its activity and its metabolic stability². When present in chiral ligands³, catalysts⁴ and auxiliaries⁵, quaternary centres can guide reactions toward both improved and unique regio-, stereo- and/or enantioselectivity. However, owing to

SUBMITTER: Hu P 

PROVIDER: S-EPMC7062202 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature