Transplantation-Induced Ischemia-Reperfusion Injury Modulates Antigen Presentation by Donor Renal CD11c⁺F4/80⁺ Macrophages through IL-1R8 Regulation.

ABSTRACT:

Background

In donor kidneys subjected to ischemia-reperfusion injury during kidney transplant, phagocytes coexpressing the F4/80 and CD11c molecules mediate proinflammatory responses and trigger adaptive immunity in transplantation through antigen presentation. After injury, however, resident renal macrophages coexpressing these surface markers acquire a proreparative phenotype, which is pivotal in controlling inflammation and fibrosis. No data are currently available regarding the effects of transplant-induced ischemia-reperfusion injury on the ability of donor-derived resident renal macrophages to act as professional antigen-presenting cells.

Methods

We evaluated the phenotype and function of intragraft CD11c⁺F4/80⁺ renal macrophages after cold ischem

SUBMITTER: Aiello S 

PROVIDER: S-EPMC7062225 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature