A Randomized Trial of Distal Diuretics versus Dietary Sodium Restriction for Hypertension in Chronic Kidney Disease.

ABSTRACT:

Background

Distal diuretics are considered less effective than loop diuretics in CKD. However, data to support this perception are limited.

Methods

To investigate whether distal diuretics are noninferior to dietary sodium restriction in reducing BP in patients with CKD stage G3 or G4 and hypertension, we conducted a 6-week, randomized, open-label crossover trial comparing amiloride/hydrochlorothiazide (5 mg/50 mg daily) with dietary sodium restriction (60 mmol per day). Antihypertension medication was discontinued for a 2-week period before randomization. We analyzed effects on BP, kidney function, and fluid balance and related this to renal clearance of diuretics.

Results

A total of 26 patients (with a mean eGFR of 39 ml/min per 1.73 m²) completed both tre

SUBMITTER: Bovee DM 

PROVIDER: S-EPMC7062227 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature