Untargeted metabolomic profiling identifies disease-specific signatures in food allergy and asthma.

ABSTRACT:

Background

Food allergy (FA) affects an increasing proportion of children for reasons that remain obscure. Novel disease biomarkers and curative treatment options are strongly needed.

Objective

We sought to apply untargeted metabolomic profiling to identify pathogenic mechanisms and candidate disease biomarkers in patients with FA.

Methods

Mass spectrometry-based untargeted metabolomic profiling was performed on serum samples of children with either FA alone, asthma alone, or both FA and asthma, as well as healthy pediatric control subjects.

Results

In this pilot study patients with FA exhibited a disease-specific metabolomic signature compared with both control subjects and asthmatic patients. In particular, FA was uniquely associated with a marked decrease in

SUBMITTER: Crestani E 

PROVIDER: S-EPMC7062570 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature