Genetic susceptibility, lifestyle intervention and glycemic changes among women with prior gestational diabetes.

ABSTRACT:

Aims

Women with prior gestational diabetes mellitus (GDM) or high genetic susceptibility are prone to development of type 2 diabetes. We examined whether a lifestyle intervention modified the genetic effect on changes in glycemic markers among women with prior GDM.

Research design and methods

This study included 560 women with prior GDM from a randomized controlled trial, the Tianjin Gestational Diabetes Mellitus Prevention Program, who were assigned into an intervention arm (improved physical activity and healthy dietary intakes) or a control arm. We assessed associations of GDM related genetic variants in/near the CDKAL1 (rs7754840) and MTNR1B (rs10830962) genes with changes in fasting levels of glucose and insulin, β-cell function (HOMA-B) and insulin resistance (HOMA-IR)

SUBMITTER: Liang Z 

PROVIDER: S-EPMC7062571 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature