Effect of fabric on the accuracy of computed tomography-based finite element analyses of the vertebra.

ABSTRACT: Quantitative computed tomography (QCT)-based finite element (FE) models of the vertebra are widely used in studying spine biomechanics and mechanobiology, but their accuracy has not been fully established. Although the models typically assign material properties based only on local bone mineral density (BMD), the mechanical behavior of trabecular bone also depends on fabric. The goal of this study was to determine the effect of incorporating measurements of fabric on the accuracy of FE predictions of vertebral deformation. Accuracy was assessed by using displacement fields measured via digital volume correlation-applied to time-lapse microcomputed tomography (μCT)-as the gold standard. Two QCT-based FE models were generated from human L1 vertebrae (n = 11): the entire vertebral body and a

SUBMITTER: Wu Y 

PROVIDER: S-EPMC7062572 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature