MiR-143 promotes angiogenesis and osteoblast differentiation by targeting HDAC7.

ABSTRACT: The regulation of bone formation and detailed mechanisms are still largely elusive, and the roles of microRNAs in this process have attracted much attention. Recently, a specific subtype of CD31^hiendomucin^hi (CD31^hiEMCN^hi) endothelium has been identified to promote bone formation, together with osteoblast development. However, the role of microRNA143 in the generation of CD31^hi EMCN^hi endothelium and bone formation remains unknown. In this study, we found that miR-143 was expressed both in osteoblast cells and CD31^hiEMCN^hi endothelial cells. Serum miR-143 level was negatively correlated with age in humans. Overexpression of miR-143 promoted osteoblast formation and angiogenic effects. Furthermore, CD31<

SUBMITTER: Wang R 

PROVIDER: S-EPMC7062786 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature