Long non-coding RNA LCAL62 / LINC00261 is associated with lung adenocarcinoma prognosis.

ABSTRACT:

Background

More than half of non-small cell lung cancer (NSCLC) patients present with metastatic disease at initial diagnosis with an estimated five-year survival rate of ~5%. Despite advances in understanding primary lung cancer oncogenesis metastatic disease remains poorly characterized. Recent studies demonstrate important roles of long non-coding RNAs (lncRNAs) in tumor physiology and as prognostic markers. Therefore, we present the first transcriptome analysis to identify lncRNAs altered in metastatic lung adenocarcinoma leading to the discovery and characterization of the lncRNA LCAL62 as a prognostic biomarker.

Patients and methods

RNA-Seq, microarray, nanoString expression, and clinical data from 1,116 LUAD patients across six independent cohorts and 83 LUAD c

SUBMITTER: Dang HX 

PROVIDER: S-EPMC7062942 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature