MCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-X_L expression.

ABSTRACT: There have been few advances in the treatment of small-cell lung cancer (SCLC) because of the lack of targets. MCL1, a member of the anti-apoptotic BCL-2 family, may be a treatment target in several cancers, including SCLC. However, whether the expression profile of the anti-apoptotic BCL-2 family affects MCL1 inhibition strategy is unknown. A tissue microarray (TMA) was created from consecutive patients who were diagnosed with SCLC and had previously undergone surgery at Kyoto University Hospital (Kyoto, Japan) between 2001 and 2017. We used S63845, a MCL1 inhibitor, to assess the cytotoxic capacity in SCLC cell lines including a patient-derived cell line in vitro and in vivo. The combination of S63845 with navitoclax, a double BCL-X_L/BCL-2 inhibitor, was also employed to exami

SUBMITTER: Yasuda Y 

PROVIDER: S-EPMC7063049 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature