<i>Helicobacter pylori</i> Is Associated With Precancerous and Cancerous Lesions of the Gastric Cardia Mucosa: Results of a Large Population-Based Study in China.

ABSTRACT: Background: Helicobacter pylori (H. pylori) is widely accepted to be the most important cause of gastric non-cardia adenocarcinoma (GNCA), while its role in the development of gastric cardia adenocarcinoma (GCA) is not well-defined. We aimed to investigate current H. pylori infection in relation to the severity of both precancerous and cancerous lesions of the gastric cardia in an Asian population at high risk of GCA. Methods: A population-based cross-sectional study was conducted in Linzhou County, Henan Province, China. Two thousand three (2,003) randomly selected participants with data on current H. pylori infection, assayed by ¹³C-urea breath test (¹³C-UBT), and a sequence of histological diagnoses of the gastric cardia mucosa we

SUBMITTER: Xie S 

PROVIDER: S-EPMC7063085 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature