Microtubule associated protein 9 inhibits liver tumorigenesis by suppressing ERCC3.

ABSTRACT:

Background

Chromosomal instability plays an important part in cancer, but its genetic basis in liver tumorigenesis remains largely unclear. We aimed to characterize the mechanistic significance and clinical implication of mitotic regulator microtubule-associated protein 9 (MAP9) in hepatocellular carcinoma (HCC).

Methods

The biological functions of MAP9 were determined by in vitro tumorigenicity assays. Systematic MAP9 knockout mouse (MAP9^∆/∆) and hepatocyte-specific MAP9 knockout mouse (MAP9^∆/∆hep) were generated to confirm the role of MAP9 in HCC. The clinical impact of MAP9 was assessed in primary HCC tissue samples.

Findings

We found that MAP9 was frequently silenced in HCC tissue samples. The transcriptional silence of MAP9 in liver cancer c

SUBMITTER: Zhang J 

PROVIDER: S-EPMC7063135 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature