Catestatin improves insulin sensitivity by attenuating endoplasmic reticulum stress: In vivo and in silico validation.

ABSTRACT: Obesity is characterized by a state of chronic, unresolved inflammation in insulin-targeted tissues. Obesity-induced inflammation causes accumulation of proinflammatory macrophages in adipose tissue and liver. Proinflammatory cytokines released from tissue macrophages inhibits insulin sensitivity. Obesity also leads to inflammation-induced endoplasmic reticulum (ER) stress and insulin resistance. In this scenario, based on the data (specifically patterns) generated by our in vivo experiments on both diet-induced obese (DIO) and normal chow diet (NCD) mice, we developed an in silico state space model to integrate ER stress and insulin signaling pathways. Computational results successfully followed the experimental results for both DIO and NCD conditions. Chromogranin A (CgA) p

SUBMITTER: Dasgupta A 

PROVIDER: S-EPMC7063178 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature