Srsf7 Establishes the Juvenile Transcriptome through Age-Dependent Alternative Splicing in Mice.

ABSTRACT: The juvenile phase is characterized by continuously progressing physiological processes such as growth and maturation, which are accompanied by transitions in gene expression. The contribution of transcriptome dynamics to the establishment of juvenile properties remains unclear. Here, we investigated alternative splicing (AS) events in postnatal growth and elucidated the landscape of age-dependent alternative splicing (ADAS) in C57BL/6 mice. Our analysis of ADAS in the cerebral cortex, cardiomyocytes, and hepatocytes revealed numerous juvenile-specific splicing isoforms that shape the juvenile transcriptome, which in turn functions as a basis for the highly anabolic status of juvenile cells. Mechanistically, the juvenile-expressed splicing factor Srsf7 mediates ADAS, as exemplified by swit

SUBMITTER: Kadota Y 

PROVIDER: S-EPMC7063262 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature