Interindividual Variability of Functional Connectivity in Awake and Anesthetized Rhesus Macaque Monkeys.

ABSTRACT:

Background

Nonhuman primate (NHP) models are commonly used to advance our understanding of brain function and organization. However, to date, they have offered few insights into individual differences among NHPs. In large part, this is due to the logistical challenges of NHP research, which limit most studies to 5 subjects or fewer.

Methods

We leveraged the availability of a large-scale open NHP imaging resource to provide an initial examination of individual differences in the functional organization of the NHP brain. Specifically, we selected one awake functional magnetic resonance imaging dataset (Newcastle University: n = 10) and two anesthetized functional magnetic resonance imaging datasets (Oxford University: n = 19; University of California, Davis: n = 19) to examine

SUBMITTER: Xu T 

PROVIDER: S-EPMC7063583 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature