A novel transplantable model of lung cancer-associated tissue loss and disrupted muscle regeneration.

ABSTRACT:

Background

Cancer-associated muscle wasting (CAW), a symptom of cancer cachexia, is associated with approximately 20% of lung cancer deaths and remains poorly characterized on a mechanistic level. Current animal models for lung cancer-associated cachexia are limited in that they (1) primarily employ flank transplantation methods, (2) have short survival times not reflective of the patient condition, and (3) are typically performed in young mice not representative of mean patient age. This study investigates a new model for lung cancer-associated cachexia that can address these issues and also implicates muscle regeneration as a contributor to CAW.

Methods

We used tail vein injection as a method to introduce tumor cells that seed primarily in the lungs of mice. Body compositi

SUBMITTER: Arneson-Wissink PC 

PROVIDER: S-EPMC7063717 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature