The dosimetric impact of replacing the TG-43 algorithm by model based dose calculation for liver brachytherapy.

ABSTRACT:

Purpose

To compare treatment plans for interstitial high dose rate (HDR) liver brachytherapy with ¹⁹²Ir calculated according to current-standard TG-43U1 protocol with model-based dose calculation following TG-186 protocol.

Methods

We retrospectively evaluated dose volume histogram (DVH) parameters for liver, organs at risk (OARs) and clinical target volumes (CTVs) of 20 patient cases diagnosed with hepatocellular carcinoma (HCC) or metastatic colorectal cancer (mCRC). Dose calculations on a homogeneous water geometry (TG-43U1 surrogate) and on a computed tomography (CT) based geometry (TG-186) were performed using Monte Carlo (MC) simulations. The CTs were segmented based on a combination of assigning TG-186 recommended tissues to fixed Hounsfield Unit (HU) ranges

SUBMITTER: Duque AS 

PROVIDER: S-EPMC7063719 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature