Transcriptome analysis of HPV-induced warts and healthy skin in humans.

ABSTRACT:

Background

The human papillomaviruses (HPV) are a group of viruses that, depending on the strain, can cause cancer or the formation of benign growths known as warts. Scarce information exists with regard to the genetic nature of non-genital cutaneous warts induced by the human papillomavirus (HPV).

Methods

The main purpose of this study is to investigate the differences between the gene expression profiles of common warts and healthy skin in HPV-positive individuals by RNA sequencing on the Illumina HiSeq 2500. After obtaining shave biopsies of common warts and healthy skin from twelve Arab males, we were able to analyze the transcriptomes of 24 paired cases and controls.

Results

Common warts were found to possess a highly significant and unique molecular signature. M

SUBMITTER: Al-Eitan LN 

PROVIDER: S-EPMC7063766 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature