High-resolution modeling of the selection on local mRNA folding strength in coding sequences across the tree of life.

ABSTRACT:

Background

mRNA can form local secondary structure within the protein-coding sequence, and the strength of this structure is thought to influence gene expression regulation. Previous studies suggest that secondary structure strength may be maintained under selection, but the details of this phenomenon are not well understood.

Results

We perform a comprehensive study of the selection on local mRNA folding strengths considering variation between species across the tree of life. We show for the first time that local folding strength selection tends to follow a conserved characteristic profile in most phyla, with selection for weak folding at the two ends of the coding region and for strong folding elsewhere in the coding sequence, with an additional peak of selection for strong

SUBMITTER: Peeri M 

PROVIDER: S-EPMC7063772 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature