Trend analysis of the role of circular RNA in goat skeletal muscle development.

ABSTRACT: BACKGROUND:Circular RNA (circRNA) is produced during the splicing of mRNA (in addition to linear splicing) and is part of the gene regulatory network. The temporal expression patterns the different developmental stages were inseparable from these molecules' function. RESULTS:Skeletal muscles of Anhui white goat (AWG) across seven fetal to postnatal development stages were sequenced and 21 RNA sequencing libraries were constructed. We thereby identified 9090 circRNAs and analyzed their molecular properties, temporal expression patterns, and potential functions at the different stages. CircRNAs showed complexities and diversity of formation as the same host gene produces multiple isoforms of these nucleic acids with different expression profiles. The differential expression of 2881 circRNAs (DECs, P??2 and P-adj value?

SUBMITTER: Ling Y 

PROVIDER: S-EPMC7063781 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature