Gene co-expression networks are associated with obesity-related traits in kidney transplant recipients.

ABSTRACT:

Background

Obesity is common among kidney transplant recipients; However biological mediators of obesity are not well understood in this population. Because subcutaneous adipose tissue can be easily obtained during kidney transplant surgery, it provides a unique avenue for studying the mechanisms of obesity for this group. Although differential gene expression patterns were previously profiled for kidney transplant patients, gene co-expression patterns can shed light on gene modules not yet explored on the coordinative behaviors of gene transcription in biological and disease processes from a systems perspective.

Methods

In this study, we collected 29 demographic and clinical variables and matching microarray expression data for 26 kidney transplant patients. We conducted We

SUBMITTER: Jaime-Lara RB 

PROVIDER: S-EPMC7063809 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature