The impact of painful knee osteoarthritis on mortality: a community-based cohort study with over 24 years of follow-up.

ABSTRACT:

Objective

To investigate the impact of knee osteoarthritis (OA) and/or knee pain on excess mortality.

Method

We analyzed data from 4,182 participants in a community-based prospective cohort study of African American and Caucasian men and women aged ≥45 years. Participants completed knee radiographs and questionnaires at baseline and at up to three follow-ups to determine knee OA (rOA), knee pain and covariate status. Mortality was determined through 2015. We used Cox proportional hazards regression with time-varying covariates (TVC) to estimate hazard ratios (HR) and 95% confidence intervals (CI). Additional analyses stratified by sex, race and age were carried out.

Results

Median follow-up time was 14.6 years during which 1822 deaths occurred. Baseline knee radiograp

SUBMITTER: Cleveland RJ 

PROVIDER: S-EPMC7063854 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature