Association of Serum Uric Acid with Metabolic Syndrome and Its Components: A Mendelian Randomization Analysis.

ABSTRACT:

Background

The role of uric acid on metabolic syndrome (MetS) has always been controversial. This study aims to explore associations between uric acid with MetS and its components in Chinese female health check-up population.

Methods

1381 subjects constituted the longitudinal health check-up cohort. Health examination and genotyping were performed. Unadjusted and adjusted observational analyses were implemented to evaluate observational associations between uric acid with MetS and its components. Mendelian randomization analysis was performed to estimate the causal effect using variation at rs11722228 (SLC2A9) as an instrument for uric acid.

Results

An increase of 65% in risk of MetS per standard deviation increase in uric acid was found using unadjusted observ

SUBMITTER: Wang L 

PROVIDER: S-EPMC7063870 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature