Increasing Cardiovascular Data Sampling Frequency and Referencing It to Baseline Improve Hemorrhage Detection.

ABSTRACT: We hypothesize that knowledge of a stable personalized baseline state and increased data sampling frequency would markedly improve the ability to detect progressive hypovolemia during hemorrhage earlier and with a lower false positive rate than when using less granular data.

Design

Prospective temporal challenge.

Setting

Large animal research laboratory, University Medical Center.

Subjects

Fifty-one anesthetized Yorkshire pigs.

Interventions

Pigs were instrumented with arterial, pulmonary arterial, and central venous catheters and allowed to stabilize for 30 minutes then bled at a constant rate of either 5 mL·min^-1 (n = 13) or 20 (n = 38) until mean arterial pressure decreased to 40 or 30 mm Hg in the 5 and 20 mL·min^-1 pigs, r

SUBMITTER: Wertz A 

PROVIDER: S-EPMC7063895 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature