Discrepancies in Control Group Mortality Rates Within Studies Assessing Topical Antibiotic Strategies to Prevent Ventilator-Associated Pneumonia: An Umbrella Review.

ABSTRACT:

Objectives

To test the postulate that concurrent control patients within ICUs studying topical oropharyngeal antibiotics to prevent ventilator-associated pneumonia and mortality would experience spillover effects from the intervention.

Data sources

Studies cited in 15 systematic reviews of various topical antibiotic and other infection prevention interventions among ICU patients.

Study selection

Studies of topical antibiotics, stratified into concurrent control versus nonconcurrent control designs. Studies of nondecontamination-based infection prevention interventions provide additional points of reference. Studies with no infection prevention intervention provide the mortality benchmark. Data from additional studies and data reported as intention to treat were used w

SUBMITTER: Hurley JC 

PROVIDER: S-EPMC7063908 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature