A New Test for the Detection of Direct Oral Anticoagulants (Rivaroxaban and Apixaban) in the Emergency Room Setting.

ABSTRACT: Determining whether a patient has taken a direct oral anticoagulant (DOAC) is critical during the periprocedural and preoperative period in the emergency department. However, the inaccessibility of complete medical records, along with the generally inconsistent sensitivity of conventional coagulation tests to these drugs, complicates clinical decision making and puts patients at risk of uncontrollable bleeding. In this study, we evaluate the utility of inhibitor-II-X (i-II-X), a novel, microfluidics-based diagnostic assay for the detection and identification of Factor Xa inhibitors (FXa-Is) in an acute care setting.

Design

First-in-human, 91-patient, single-center retrospective pilot study.

Setting

Emergency room.

Patients

Adult patients admitted into the emergency dep

SUBMITTER: Frydman GH 

PROVIDER: S-EPMC7063952 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature