Impact of Inaccurate Documentation of Sampling and Infusion Time in Model-Informed Precision Dosing.

ABSTRACT:

Background

Routine clinical TDM data is often used to develop population pharmacokinetic (PK) models, which are applied in turn for model-informed precision dosing. The impact of uncertainty in documented sampling and infusion times in population PK modeling and model-informed precision dosing have not yet been systematically evaluated. The aim of this study was to investigate uncertain documentation of (i) sampling times and (ii) infusion rate exemplified with two anti-infectives.

Methods

A stochastic simulation and estimation study was performed in NONMEM^® using previously published population PK models of meropenem and caspofungin. Uncertainties, i.e. deviation between accurate and planned sampling and infusion times (standard deviation (SD) ± 5 min to ± 30 min

SUBMITTER: Alihodzic D 

PROVIDER: S-EPMC7063976 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature