High stromal nicotinamide N-methyltransferase (NNMT) indicates poor prognosis in colorectal cancer.

ABSTRACT:

Purpose

Nicotinamide n-methyltransferase (NNMT) has good biochemical activity and epigenetic regulation, and has been reported as a major metabolic regulator of cancer. The goal of this study was to investigate the significance of stromal NNMT expression in colorectal cancer (CRC).

Patients and methods

Stromal expression of NNMT in primary CRC, metastasis CRC, and their non-cancerous tissues from 1088 CRC patients was examined by immunohistochemistry. The associations between stromal NNMT expression and survival outcomes in 967 patients with stage I-III CRC were further evaluated with Kaplan-Meier curve and Cox model analyses.

Results

NNMT expression was mainly sourced from stromal compartments and also elevated in CRC. Patients with high stromal NNMT (IHC-score ≥ 106

SUBMITTER: Song M 

PROVIDER: S-EPMC7064029 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature