Changes in White Matter Microstructure After Electroconvulsive Therapy for Treatment-Resistant Depression.

ABSTRACT:

Background

Treatment-resistant depression is among the most debilitating conditions in psychiatry. Recent studies have associated alterations in white matter microstructure measured with magnetic resonance imaging with poor antidepressant response. Therefore, the extent to which electroconvulsive therapy, the most effective therapeutic option for treatment-resistant depression, affects white matter microstructure warrants investigation.

Methods

A total 13 patients suffering from severe unipolar treatment-resistant depression underwent magnetic resonance imaging with a diffusion tensor imaging sequence before and after undergoing a series of right unilateral electroconvulsive therapy. Diffusivity metrics were compared voxel-wise using tract-based spatial statistics and repeat

SUBMITTER: Gryglewski G 

PROVIDER: S-EPMC7064047 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature