Testing gene-environment interactions for rare and/or common variants in sequencing association studies.

ABSTRACT: The risk of many complex diseases is determined by a complex interplay of genetic and environmental factors. Advanced next generation sequencing technology makes identification of gene-environment (GE) interactions for both common and rare variants possible. However, most existing methods focus on testing the main effects of common and/or rare genetic variants. There are limited methods developed to test the effects of GE interactions for rare variants only or rare and common variants simultaneously. In this study, we develop novel approaches to test the effects of GE interactions of rare and/or common risk, and/or protective variants in sequencing association studies. We propose two approaches: 1) testing the effects of an optimally weighted combination of GE interactions for rare variant

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC7064198 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature