Pneumococcal colonisation is an asymptomatic event in healthy adults using an experimental human colonisation model.

ABSTRACT:

Introduction

Pneumococcal colonisation is regarded as a pre-requisite for developing pneumococcal disease. In children previous studies have reported pneumococcal colonisation to be a symptomatic event and described a relationship between symptom severity/frequency and colonisation density. The evidence for this in adults is lacking in the literature. This study uses the experimental human pneumococcal challenge (EHPC) model to explore whether pneumococcal colonisation is a symptomatic event in healthy adults.

Methods

Healthy participants aged 18-50 were recruited and inoculated intra-nasally with either Streptococcus pneumoniae (serotypes 6B, 23F) or saline as a control. Respiratory viral swabs were obtained prior to inoculation. Nasal and non-nasal symptoms were then asses

SUBMITTER: Trimble A 

PROVIDER: S-EPMC7064211 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature