Gestational Exposures to Phthalates and Folic Acid, and Autistic Traits in Canadian Children.

ABSTRACT:

Background

The etiology of autism spectrum disorder is poorly understood. Few studies have investigated the link between endocrine-disrupting chemicals and autistic traits. We examined the relationship between gestational phthalates and autistic traits in 3- to 4-y-old Canadian children. We also investigated potential effect modification by sex and folic acid supplementation.

Methods

We enrolled 2,001 women>18 years of age during the first trimester of pregnancy between 2008 and 2011 from 10 cities in Canada. At 3-4 years of age, 610 children underwent neuropsychological assessments including the Social Responsiveness Scale-II (SRS-2) as a measure of autistic traits and social impairment. We measured 11 phthalate metabolites in maternal first trimester urine samples and asse

SUBMITTER: Oulhote Y 

PROVIDER: S-EPMC7064316 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature