CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity.

ABSTRACT:

Background

Endocrine disrupting chemicals (EDCs) are xenobiotics that mimic the interaction of natural hormones and alter synthesis, transport, or metabolic pathways. The prospect of EDCs causing adverse health effects in humans and wildlife has led to the development of scientific and regulatory approaches for evaluating bioactivity. This need is being addressed using high-throughput screening (HTS) in vitro approaches and computational modeling.

Objectives

In support of the Endocrine Disruptor Screening Program, the U.S. Environmental Protection Agency (EPA) led two worldwide consortiums to virtually screen chemicals for their potential estrogenic and androgenic activities. Here, we describe the Collaborative Modeling Project for Androgen Receptor Activity (CoMPARA)

SUBMITTER: Mansouri K 

PROVIDER: S-EPMC7064318 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature