Neuroanatomical Risk Factors for Posttraumatic Stress Disorder in Recent Trauma Survivors.

ABSTRACT:

Background

Low hippocampal volume could serve as an early risk factor for posttraumatic stress disorder (PTSD) in interaction with other brain anomalies of developmental origin. One such anomaly may well be the presence of a large cavum septum pellucidum (CSP), which has been loosely associated with PTSD. We performed a longitudinal prospective study of recent trauma survivors. We hypothesized that at 1 month after trauma exposure the relation between hippocampal volume and PTSD symptom severity will be moderated by CSP volume, and that this early interaction will account for persistent PTSD symptoms at subsequent time points.

Methods

One hundred seventy-one adults (87 women, average age 34.22 years [range, 18-65 years of age]) who were admitted to a general hospital's emerg

SUBMITTER: Ben-Zion Z 

PROVIDER: S-EPMC7064406 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature