Magnetoencephalographic Correlates of Suicidal Ideation in Major Depression.

ABSTRACT:

Background

Defining the neurobiological underpinnings of suicidal ideation (SI) is crucial to improving our understanding of suicide. This study used magnetoencephalographic gamma power as a surrogate marker for population-level excitation-inhibition balance to explore the underlying neurobiology of SI and depression. In addition, effects of pharmacological intervention with ketamine, which has been shown to rapidly reduce SI and depression, were assessed.

Methods

Data were obtained from 29 drug-free patients with major depressive disorder who participated in an experiment comparing subanesthetic ketamine (0.5 mg/kg) with a placebo saline infusion. Magnetoencephalographic recordings were collected at baseline and after ketamine and placebo infusions. During scanning, patient

SUBMITTER: Gilbert JR 

PROVIDER: S-EPMC7064429 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature