Microlocalization and clinical significance of stabilin-1⁺ macrophages in treatment-naive patients with urothelial carcinoma of the bladder.

ABSTRACT:

Purpose

Emerging evidence has shown that macrophages (Mφs) at different tumor sites have diverse clinical attributes. Stabilin-1 is a multi-functional scavenger marker for specialized tumor-associated Mφs. This study investigates the relationship between the density and microlocalization of stabilin-1⁺ Mφs within tumors and the clinical outcomes of patients with urothelial carcinoma of the bladder (UCB).

Methods

In this retrospective study, 283 UCB patients who received radical cystectomy or transurethral resection were examined. Immunohistochemistry and immunofluorescence analyses were used to colocalize the expression of stabilin-1 with other markers for Mφs (CD14, CD68, CD163, and CD206). Kaplan-Meier analysis and Cox proportional hazards regression models were

SUBMITTER: Wang B 

PROVIDER: S-EPMC7064462 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature