Diversity and Complexity of the Large Surface Protein Family in the Compacted Genomes of Multiple <i>Pneumocystis</i> Species.

ABSTRACT: Pneumocystis, a major opportunistic pathogen in patients with a broad range of immunodeficiencies, contains abundant surface proteins encoded by a multicopy gene family, termed the major surface glycoprotein (Msg) gene superfamily. This superfamily has been identified in all Pneumocystis species characterized to date, highlighting its important role in Pneumocystis biology. In this report, through a comprehensive and in-depth characterization of 459 msg genes from 7 Pneumocystis species, we demonstrate, for the first time, the phylogeny and evolution of conserved domains in Msg proteins and provide a detailed description of the classification, unique characteristics, and phylogenetic relatedness of five Msg families. We further describe, for the first tim

SUBMITTER: Ma L 

PROVIDER: S-EPMC7064768 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature