Phylogeography and Genetic Diversity of Francisella tularensis subsp. holarctica in France (1947-2018).

ABSTRACT: In France, tularemia is caused by Francisella tularensis subsp. holarctica and is a sporadic disease affecting mainly wildlife animals and humans. F. tularensis species presents low genetic diversity that remains poorly described in France, as only a few genomes of isolates from the country are available so far. The objective of this study was to characterize the genetic diversity of F. tularensis in France and describe the phylogenetic distribution of isolates through whole-genome sequencing and molecular typing. Whole genomes of 350 strains of human or animal origin, collected from 1947 to 2018 in France and neighboring countries, were sequenced. A preliminary classification using the established canonical single nucleotide polymorphism (canSNP) nomenclature w

SUBMITTER: Kevin M 

PROVIDER: S-EPMC7064806 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature