The Inhibition of Aldose Reductase Accelerates Liver Regeneration through Regulating Energy Metabolism.

ABSTRACT:

Objectives

Our previous study showed that aldose reductase (AR) played key roles in fatty liver ischemia-reperfusion (IR) injury by regulating inflammatory response and energy metabolism. Here, we aim to investigate the role and mechanism of AR in the regeneration of normal and fatty livers after liver surgery.

Methods

The association of AR expression with liver regeneration was studied in the rat small-for-size liver transplantation model and the mice major hepatectomy and hepatic IR injury model with or without fatty change. The direct role and mechanism of AR in liver regeneration was explored in the AR knockout mouse model.

Results

Delayed regeneration was detected in fatty liver after liver surgery in both rat and mouse models. Furthermore, the expression of AR w

SUBMITTER: Li CX 

PROVIDER: S-EPMC7064854 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature