Association of Baseline Inflammation With Effectiveness of Nutritional Support Among Patients With Disease-Related Malnutrition: A Secondary Analysis of a Randomized Clinical Trial.

ABSTRACT:

Importance

Inflammation is a key driver of malnutrition during illness and is often accompanied by metabolic effects, including insulin resistance and reduction of appetite. However, it still remains unclear if inflammation influences the response to nutritional support among patients with disease-related malnutrition.

Objective

To examine whether patients' baseline inflammatory status is associated with the effect of nutritional support on 30-day mortality.

Design, setting, and participants

This is a secondary analysis of the Effect of Early Nutritional Support on Frailty, Functional Outcomes, and Recovery of Malnourished Medical Inpatients Trial (EFFORT), a randomized clinical trial conducted in 8 Swiss hospitals from April 2014 to February 2018. A total of 1950 par

SUBMITTER: Merker M 

PROVIDER: S-EPMC7064875 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature