Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients.

ABSTRACT: Neuronal loss is the best neuropathological substrate that correlates with cortical atrophy and dementia in Alzheimer's disease (AD). Defective GABAergic neuronal functions may lead to cortical network hyperactivity and aberrant neuronal oscillations and in consequence, generate a detrimental alteration in memory processes. In this study, using immunohistochemical and stereological approaches, we report that the two major and non-overlapping groups of inhibitory interneurons (SOM-cells and PV-cells) displayed distinct vulnerability in the perirhinal cortex of APP/PS1 mice and AD patients. SOM-positive neurons were notably sensitive and exhibited a dramatic decrease in the perirhinal cortex of 6-month-old transgenic mice (57% and 61% in areas 36 and 35, respectively) and, most importantly,

SUBMITTER: Sanchez-Mejias E 

PROVIDER: S-EPMC7064898 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature