Synthesis and Characterization of an Epidermal Growth Factor Receptor-Selective Ru^II Polypyridyl-Nanobody Conjugate as a Photosensitizer for Photodynamic Therapy.

ABSTRACT: There is a current surge of interest in the development of novel photosensitizers (PSs) for photodynamic therapy (PDT), as those currently approved are not completely ideal. Among the tested compounds, we have previously investigated the use of Ru^II polypyridyl complexes with a [Ru(bipy)₂ (dppz)]²⁺ and [Ru(phen)₂ (dppz)]²⁺ scaffold (bipy=2,2'-bipyridine; dppz=dipyrido[3,2-a:2',3'-c]phenazine; phen=1,10-phenanthroline). These complexes selectively target DNA. However, because DNA is ubiquitous, it would be of great interest to increase the selectivity of our PDT PSs by linking them to a targeting vector in view of targeted PDT. Herein, we present the synthesis, characterization, and in-depth photophysical evaluation of a nanobody-contai

SUBMITTER: Karges J 

PROVIDER: S-EPMC7065149 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature