Interleaved ³¹ P MRS/¹ H ASL for analysis of metabolic and functional heterogeneity along human lower leg muscles at 7T.

ABSTRACT:

Purpose

MR offers the unique possibility to noninvasively investigate cellular energy metabolism via 31P MRS, while blood perfusion, which provides oxygen and substrates to the tissue, is accessible by arterial spin labeling (ASL) 1H MRI. Because metabolic and hemodynamic parameters are linked, it would be desirable to study them simultaneously. A 3D-resolved method is presented that allows such measurements with high spatiotemporal resolution and has the potential to discern differences along an exercising muscle.

Methods

Multi-voxel localized ³¹ P MRS was temporally interleaved with multi-slice pASL 1H MRI. Phosphorus spectra were collected from two adjacent positions in gastrocnemius medialis (GM) during rest, submaximal plantar flexion exercise and recovery, w

SUBMITTER: Niess F 

PROVIDER: S-EPMC7065182 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature