Pyridachlometyl has a novel anti-tubulin mode of action which could be useful in anti-resistance management.

ABSTRACT:

Background

Fungicide resistance is a growing problem affecting many crop pathogens owing to the low success rate in finding novel chemical classes of fungicides. Pyridachlometyl is a new fungicide that seems to belong to a new chemical class of tubulin polymerization promoters.

Results

Pyridachlometyl exhibited potent antifungal activity against a broad range of fungal species belonging to the phyla Ascomycota and Basidiomycota. No cross-resistance was observed with other fungicide classes, such as ergosterol biosynthesis inhibitors, respiratory inhibitors, or tubulin polymerization inhibitors in Zymoseptoria tritici. Pyridachlometyl-resistant strains were obtainable by UV mutagenesis in Z. tritici and Penicillium digitatum. Mutations in tubulin-coding genes were found in al

SUBMITTER: Matsuzaki Y 

PROVIDER: S-EPMC7065193 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature