Uric Acid as a Potential Peripheral Biomarker for Disease Features in Huntington's Patients.

ABSTRACT: Oxidative stress has long been implicated in the pathophysiology and progression of Huntington's disease (HD). Uric acid (UA) is a naturally occurring antioxidant that is present in the brain and periphery. Growing evidence has implicated UA as a molecular biomarker for several neurodegenerative diseases, most notably Parkinson's disease (PD). In this study, we investigated UA levels in clinical samples from HD patients and normal controls (NCs) and assessed potential relationships between UA levels and disease and clinical data. UA levels were measured in plasma (n = 107) and saliva (n = 178) samples from premanifest (pre-HD) and manifest HD patients and control subjects. Gender effects of UA levels were observed in both biofluids, with male patients showing higher UA levels compared to f

SUBMITTER: Corey-Bloom J 

PROVIDER: S-EPMC7065265 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature