Individualizing the dosage of Methylphenidate in children with attention deficit hyperactivity disorder.

ABSTRACT:

Background

Attention deficit hyperactivity disorder (ADHD) is one of the most common childhood mental health disorders. Stimulant drugs as the most commonly used treatment and first-line therapy for ADHD have side effects. One of the newest approaches to select the best choices and optimize dosages of medications is personalized medicine.

Methods

This historical cohort study was carried out on the data taken from the period of 2008 to 2015. Eligible subjects were included in the study randomly. We used mixed-effects logistic regression models to personalize the dosage of Methylphenidate (MPH) in ADHD. The patients' heterogeneity was considered using subject-specific random effects, which are treated as the realizations of a stochastic process. To recommend a personalized dos

SUBMITTER: Shirafkan H 

PROVIDER: S-EPMC7065304 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature