Epigenetic predictors of all-cause mortality are associated with objective measures of neighborhood disadvantage in an urban population.

ABSTRACT:

Background

Neighborhood characteristics are robust predictors of overall health and mortality risk for residents. Though there has been some investigation of the role that molecular indicators may play in mediating neighborhood exposures, there has been little effort to incorporate newly developed epigenetic biomarkers into our understanding of neighborhood characteristics and health outcomes.

Methods

Using 157 participants of the Detroit Neighborhood Health Study with detailed assessments of neighborhood characteristics and genome-wide DNA methylation profiling via the Illumina 450K methylation array, we assessed the relationship between objective neighborhood characteristics and a validated DNA methylation-based epigenetic mortality risk score (eMRS). Associations were adj

SUBMITTER: Ward-Caviness CK 

PROVIDER: S-EPMC7065313 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature