Yin-Yang 1 regulates effector cytokine gene expression and T(H)2 immune responses.

ABSTRACT:

Background

The transcription factor Yin-Yang 1 (YY-1) binds to the promoter regions of several T-cell cytokine genes, but the expression and contribution of this factor to cytokine gene expression and T-cell activation in vivo is not clear.

Objective

We sought to better define the role of YY-1 in T-cell gene regulation and allergic immune responses.

Methods

We studied cytokine gene expression in T lymphocytes isolated from wild-type mice and heterozygous littermates bearing 1 targeted yy-1 allele (yy-1(+/-) mice). T cells were stimulated with anti-T-cell receptor (anti-TCR) plus CD28 antibodies or with peptide antigen plus antigen-presenting cells by using newly generated yy-1(+/-) TCR transgenic mice. We also studied ovalbumin-driven allergic immune responses in a mo

SUBMITTER: Guo J 

PROVIDER: S-EPMC7065358 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature